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Delicious Cattle Drive Casserole with beef, vegetables, and cheese

Cattle Drive Casserole

A hearty casserole featuring savory beef, a biscuit crust, and a creamy cheese layer, perfect for weeknight dinners or potlucks.
Prep Time 20 minutes
Cook Time 35 minutes
Total Time 55 minutes
Course Dinner, Main Course
Cuisine American
Servings 8 servings
Calories 450 kcal

Ingredients
  

For the Beef Mixture

  • 1.5 pounds Lean Ground Beef Brown and drain fat
  • 1 Red Bell Pepper seeded, chopped Adds flavor and color
  • 1 Yellow Onion chopped Sauté for sweetness
  • 1 ounce Taco Seasoning Mix For flavor

For the Biscuit Base

  • 2.5 cups Biscuit Mix, like Bisquick Use for the base crust
  • 1 cup Water To mix with biscuit mix
  • Cooking Spray like Pam For greasing the casserole dish

For the Cheese Layer

  • ½ cup Sour Cream Adds creaminess
  • ½ cup Mayonnaise Can substitute with Greek yogurt
  • 4 ounces Diced Green Chiles, drained For a mild heat
  • 1.5 cups Cheddar Cheese, Fiesta Blend, shredded Divided for layering
  • 1 teaspoon Garlic Powder For added flavor
  • ½ cup Salsa, mild For topping

Instructions
 

Preparation

  • Preheat the oven to 350℉.
  • In a large skillet over medium-high heat, add the ground beef and break it apart with a spoon. Cook until no longer pink, stirring occasionally. Drain off extra fat.
  • In a mixing bowl, combine the biscuit mix and water. Stir until well mixed. Spray a 9 x 13 inch casserole dish with cooking spray. Press the biscuit dough into the dish and spread to the edges. Bake for 5–8 minutes, until set and lightly golden. Keep the oven on.

Cooking

  • Add the chopped onion and red bell pepper to the cooked beef. Stir and cook for about 4 minutes. Add taco seasoning and mix well. Remove from heat.
  • Spread the cooked beef mixture evenly over the baked biscuit layer.
  • In a medium bowl, combine sour cream, mayonnaise, drained green chiles, ¾ cup shredded cheese, and garlic powder. Mix until smooth and carefully spread this over the beef layer.
  • Add small spoonfuls of salsa over the sour cream layer and sprinkle the remaining shredded cheese on top.
  • Bake the casserole, uncovered, for 30 minutes or until hot and bubbly.

Notes

Drain the beef well to avoid a soggy casserole. Press biscuit dough evenly for consistent baking. Let the casserole rest for 5–10 minutes after baking to make cutting easier.
Keyword Beef Casserole, Biscuit Casserole, Casserole, Cattle Drive Casserole, comfort food
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